Research

Risk Prediction Score for Pediatric Patients with Suspected Ebola Virus Disease

Rapid diagnostic tools for children with Ebola virus disease (EVD) are needed to expedite isolation and treatment. To evaluate a predictive diagnostic tool, we examined retrospective data (2014–2015) from the International Medical Corps Ebola Treatment Centers in West Africa. We incorporated statistically derived candidate predictors into a 7-point Pediatric Ebola Risk Score. Evidence of bleeding or having known or no known Ebola contacts was positively associated with an EVD diagnosis, whereas abdominal pain was negatively associated. Model discrimination using area under the curve (AUC) was 0.87, which outperforms the World Health Organization criteria (AUC 0.56). External validation, performed by using data from International Medical Corps Ebola Treatment Centers in the Democratic Republic of the Congo during 2018–2019, showed an AUC of 0.70. External validation showed that discrimination achieved by using World Health Organization criteria was similar; however, the Pediatric Ebola Risk Score is simpler to use.

Start Date:2020

End Date:2022

Partners: Brown University
University of Massachusetts
University of Georgia
Liberia Ministry of Health

Donors: National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)
Rhode Island Foundation

Publications: Emerging Infectious Diseases